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Are fish oil omega-3 long-chain fatty acids and their derivatives peroxisome proliferator-activated receptor agonists?

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Peroxisome proliferator-activated receptors in vascular biology-molecular mechanisms and clinical implications.

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A rapid, homogeneous, fluorescence polarization binding assay for peroxisome proliferator-activated receptors alpha and gamma using a fluorescein-tagged dual PPARalpha/gamma activator.

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Peroxisome proliferator-activated receptor alpha interacts with high affinity and is conformationally responsive to endogenous ligands.

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Synthesis, biological evaluation, and molecular modeling investigation of new chiral fibrates with PPARalpha and PPARgamma agonist activity.

Pinelli A, Godio C, Laghezza A, Mitro N, Fracchiolla G, Tortorella V, Lavecchia A, Novellino E, Fruchart JC, Staels B, Crestani M, Loiodice F.

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Structural determinants of the agonist-independent association of human peroxisome proliferator-activated receptors with coactivators.

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Sulfur-substituted and alpha-methylated fatty acids as peroxisome proliferator-activated receptor activators.

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Synthesis of docosahexaenoic acid derivatives designed as novel PPARgamma agonists and antidiabetic agents.

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PAR-5359, a well-balanced PPARalpha/gamma dual agonist, exhibits equivalent antidiabetic and hypolipidemic activities in vitro and in vivo.

Kim MK, Chae YN, Son MH, Kim SH, Kim JK, Moon HS, Park CS, Bae MH, Kim E, Han T, Choi HH, Shin YA, Ahn BN, Lee CH, Lim JI, Shin CY.

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T2384, a novel antidiabetic agent with unique peroxisome proliferator-activated receptor gamma binding properties.

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Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family.

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Peroxisome proliferator-activated receptors and atherogenesis: regulators of gene expression in vascular cells.

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Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors alpha - and gamma-mediated gene expression via liver fatty acid binding protein: a signaling path to the nucleus.

Wolfrum C, Borrmann CM, Borchers T, Spener F.

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