Metabolic memory: a vascular perspective
Profil Institut für Stoffwechselforschung, Hellersbergstrasse 9, 41460 Neuss, Germany
Herzzentrum Wuppertal, Medizinische Klinik 3, Helios Klinikum, Universität Witten/Herdecke, Germany
Cardiovascular Diabetology 2010, 9:51 doi:10.1186/1475-2840-9-51Published: 14 September 2010
First paragraph (this article has no abstract)
Multiple and complex pathways promote the deleterious effects of hyperglycemia in diabetes, ultimately leading to micro- and macrovascular disease. Some of the known mechanisms in diabetic vascular disease may explain the initiation of the "metabolic memory", but fall short if long periods of time are involved.