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Open Access Original investigation

Brain natriuretic peptide is related to diastolic dysfunction whereas urinary albumin excretion rate is related to left ventricular mass in asymptomatic type 2 diabetes patients

Martin Magnusson1*, Stefan Jovinge23, Kambiz Shahgaldi4, Bo Israelsson1, Leif Groop5 and Olle Melander5

Author Affiliations

1 Department of Cardiology, Malmö University Hospital, Lund University, Lund, Sweden

2 Department of Cardiology, Lund University Hospital, Lund University, Lund, Sweden

3 Lund Strategic Research Centre for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden

4 Department of Cardiology, Karoliniska University Hospital, Stockholm University, Sweden

5 Lund University Diabetes Centre, Clinical Research Centre, Malmö University Hospital, Lund University, Sweden

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Cardiovascular Diabetology 2010, 9:2  doi:10.1186/1475-2840-9-2

Published: 18 January 2010

Abstract

Background

The aims of this study were to estimate the prevalence of left ventricular systolic (LVSD) and diastolic (LVDD) dysfunction, and to test if BNP and urinary albumin excretion rate (AER) are related to LVSD, LVD and left ventricular mass (LVM) in asymptomatic type 2 diabetes patients.

Methods

Presence of LVSD, LVDD and LVM, determined with echocardiography, was related to levels of BNP and AER in 153 consecutive asymptomatic patients with type 2 diabetes.

Results

LVSD was present in 6.1% of patients whereas 49% (29% mild, 19% moderate and 0.7% severe) had LVDD and 9.4% had left ventricular hypertrophy. Increasing age (P < 0.0001) was the only independent variable related to mild LVDD whereas increasing BNP (P = 0.01), systolic blood pressure (P = 0.01), age (P = 0.003) and female gender (P = 0.04) were independent determinants of moderate to severe LVDD. AER (P = 0.003), age (P = 0.01) and male gender (P = 0.006) were directly and independently related to LVM.

Conclusion

About half of asymptomatic type 2 diabetes patients have LVDD. Of those, more than one third display moderate LVDD pattern paralleled by increases in BNP, suggesting markedly increased risk of heart failure, especially in females, whereas AER and male sex are related to LVM.