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Open Access Highly Accessed Original investigation

The impact of diabetes on coronary heart disease differs from that on ischaemic stroke with regard to the gender

Marjukka Hyvärinen1*, Jaakko Tuomilehto12, Tiina Laatikainen2, Stefan Söderberg3, Mats Eliasson3, Peter Nilsson4 and Qing Qiao12

Author Affiliations

1 Department of Public Health, University of Helsinki, Helsinki, Finland

2 Diabetes Prevention Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

3 Department of Public Health and Clinical Medicine, Umeå University Hospital SE-901 85 Umeå, Sweden

4 Department of Clinical Sciences, Lund University University Hospital, S-205 02 Malmö, Sweden

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Cardiovascular Diabetology 2009, 8:17  doi:10.1186/1475-2840-8-17

Published: 24 March 2009

Abstract

Background

To study the diabetes related CVD risk between men and women of different ages.

Methods

Hazards ratios (HRs) (95%CI) for acute CHD and ischaemic stroke events were estimated based on data of Finnish and Swedish cohorts of 5111 women and 4167 men.

Results

182 (3.6%) women and 348 (8.4%) men had CHD and 129 (2.5%) women and 137 (3.3%) men ischaemic stroke events. The multivariate adjusted HRs for acute CHD at age groups of 40–49, 50–59 and 60–69 years were 1.00 (1.94), 1.78 (4.23), 3.75 (8.40) in women (men) without diabetes and 4.35 (5.40), 5.49 (9.54) and 8.84 (13.76) in women (men) with diabetes. The corresponding HRs for ischaemic stroke were 1.00 (1.26), 2.48 (2.83) and 5.17 (5.11) in women (men) without diabetes and 4.14 (4.91), 3.32 (6.75) and 13.91 (18.06) in women (men) with diabetes, respectively.

Conclusion

CHD risk was higher in men than in women but difference reduced in diabetic population. Diabetes, however, increased stroke risk more in men than in women.