Figure 1.

Products of polyol pathway, sorbitol (A) and fructose (B) were measured in the hearts from 12 weeks and 48 weeks diabetic (DM) BBZ rats and their age matched non-diabetic (ND) controls. Diabetes duration of 12 weeks (n = 9) and 48 weeks (n = 6) were used in this study. ARI denotes treatment with the aldose reductase inhibitor zopolrestat, while SDI denotes treatment with sorbitol dehydrogenase inhibitor.