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Change from baseline in 24-h ambulatory BP and heart rate at 6 and 12 months |
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| Background metformin |
Background sulfonylurea |
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|
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| + rosiglitazone (n = 176) |
+ sulfonylurea (n = 165) |
difference (95% CI), p-value |
+ rosiglitazone (n = 160) |
+ metformin (n = 167) |
difference (95% CI), p-value |
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| ystolic BP change (mmHg) |
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| 6 months |
-3.1 (-4.8, -1.4) |
-1.6 (-3.5, + 0.3) |
-1.5 (-3.6, 0.6), NS |
-3.8 (-5.8, -1.8) |
-1.2 (-3.0, + 0.7) |
-2.7 (-4.9, -0.5), 0.015 |
| 12 months |
-4.9 (-6.7, -3.2) |
-2.2 (-4.2, -0.3) |
-2.7 (-4.9, -0.5), 0.016 |
-3.8 (-5.9, -1.8) |
-1.3 (-3.3, + 0.7) |
-2.5 (-4.8, -0.2), 0.031 |
| Diastolic BP change (mmHg) |
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| 6 months |
-2.8 (-3.8, -1.9) |
-1.6 (-2.7, -0.5) |
-1.3 (-2.5, -0.0), 0.049 |
-3.1 (-4.2, -2.0) |
-0.4 (-1.6, + 0.7) |
-2.7 (-4.0, -1.4), < 0.001 |
| 12 months |
-3.8 (-4.9, -2.7) |
-1.7 (-2.9, -0.5) |
-2.1 (-3.4, -0.7), 0.003 |
-3.7 (-4.9, -2.5) |
-0.6 (-1.7, + 0.6) |
-3.1 (-4.5, -1.8), < 0.001 |
| Heart rate change (beat/min) |
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| 6 months |
-0.4 (-1.6, + 0.8) |
-0.1 (-1.3, + 1.0) |
-0.3 (-1.7, 1.1), NS |
-0.7 (-1.9, + 0.5) |
1.3 (+ 0.1, + 2.6) |
-2.0 (-3.4, -0.6), 0.006 |
| 12 months |
-0.9 (-2.2, + 0.4) |
0.0 (-1.3, + 1.3) |
-0.9 (-2.5, 0.7), NS |
-0.9 (-2.3, + 0.5) |
1.7 (+ 0.3, + 3.1) |
-2.6 (-4.2, -1.0), 0.002 |
|
Modified ITT population; data are model-adjusted mean (95% CI), or number | ||||||
Komajda et al. Cardiovascular Diabetology 2008 7:10 doi:10.1186/1475-2840-7-10 |
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