|
Distribution of selected clinical and metabolic factors across categories of impaired glucose regulation |
|||||
| Variable |
NFG |
IFG/NGT |
IFG/IGT |
DM |
z-trend* |
|
|
|||||
| Men |
|||||
| Clinical and metabolic data (n) |
316 |
98 |
73 |
81 |
8.1 |
| Age (years) |
42.5 ± 0.6 |
45.1 ± 0.9 |
49.3 ± 1.1 |
52.7 ± 1.0 |
5.9 |
| Body mass index (kg/m2) |
24.6 ± 0.3 |
26.6 ± 0.4 |
26.6 ± 0.5 |
27.7 ± 0.6 |
8.2 |
| Waist circumference (cm) |
85.8 ± 0.6 |
92.5 ± 1.0 |
93.0 ± 1.4 |
97.5 ± 1.3 |
7.8 |
| Serum fasting insulin (pmol/l) |
10.8 ± 0.4 |
14.2 ± 0.8 |
19.8 ± 2.4 |
20.9 ± 2.1 |
6.9 |
| Triglycerides (mmol/l) |
0.97 ± 0.03 |
1.20 ± 0.07 |
1.56 ± 0.19 |
1.76 ± 0.17 |
2.5 |
| LDL cholesterol (mmol/l) |
3.42 ± 0.07 |
3.60 ± 0.13 |
3.83 ± 0.14 |
3.75 ± 0.17 |
-3.8 |
| HDL cholesterol (mmol/l) |
1.42 ± 0.03 |
1.29 ± 0.05 |
1.27 ± 0.06 |
1.20 ± 0.05 |
8.0 |
| Systolic blood pressure (mmHg) |
127 ± 0.9 |
132 ± 1.6 |
137 ± 1.9 |
145 ± 2.3 |
|
| Mean intima-media thickness (n) |
104 |
46 |
48 |
50 |
2.4 |
| Carotid (mm) |
0.72 ± 0.01 |
0.71 ± 0.02 |
0.78 ± 0.03 |
0.75 ± 0.02 |
5.2 |
| Femoral (mm) |
0.93 ± 0.06 |
0.92 ± 0.09 |
1.20 ± 0.10 |
1.41 ± 0.13 |
4.9 |
| Total (mm) |
0.76 ± 0.02 |
0.82 ± 0.04 |
0.90 ± 0.03 |
1.04 ± 0.04 |
|
| Women |
|||||
| Clinical and metabolic data (n) |
460 |
47 |
77 |
103 |
|
| Age (years) |
41.4 ± 0.5 |
52.1 ± 1.4 |
50.1 ± 1.0 |
54.4 ± 0.8 |
11.9 |
| Body mass index (kg/m2) |
27.1 ± 0.3 |
31.5 ± 0.9 |
31.8 ± 0.7 |
31.8 ± 0.5 |
8.4 |
| Waist circumference (cm) |
86.7 ± 0.6 |
100.1 ± 2.1 |
97.4 ± 1.4 |
101.5 ± 1.1 |
10.7 |
| Serum fasting insulin (pmol/l) |
13.8 ± 0.4 |
21.1 ± 1.9 |
19.4 ± 1.4 |
25.4 ± 2.1 |
8.4 |
| Triglycerides (mmol/l) |
0.82 ± 0.02 |
1.07 ± 0.08 |
1.10 ± 0.1 |
1.35 ± 0.08 |
8.8 |
| LDL cholesterol (mmol/l) |
3.44 ± 0.05 |
4.11 ± 0.19 |
3.81 ± 0.14 |
4.20 ± 0.14 |
5.8 |
| HDL cholesterol (mmol/l) |
1.40 ± 0.02 |
1.32 ± 0.05 |
1.28 ± 0.0 |
1.21 ± 0.04 |
-5.0 |
| Systolic blood pressure (mmHg) |
120 ± 0.7 |
137 ± 3.8 |
134 ± 2.1 |
139 ± 1.9 |
10.3 |
| Mean intima-media thickness (n) |
155 |
30 |
45 |
76 |
|
| Carotid (mm) |
0.69 ± 0.01 |
0.75 ± 0.02 |
0.74 ± 0.04 |
0.84 ± 0.03 |
5.6 |
| Femoral (mm) |
0.71 ± 0.03 |
0.88 ± 0.09 |
0.84 ± 0.06 |
1.16 ± 0.07 |
6.5 |
| Total (mm) |
0.76 ± 0.02 |
0.82 ± 0.04 |
0.90 ± 0.03 |
1.04 ± 0.04 |
7.4 |
| Overall |
|||||
| Clinical and metabolic data (n) |
776 |
145 |
150 |
184 |
|
| Age (years) |
41.8 ± 0.4 |
47.4 ± 0.8 |
49.7 ± 0.7 |
53.7 ± 0.6 |
14.3 |
| Body mass index (kg/m2) |
26.0 ± 0.2 |
27.8 ± 0.4 |
29.0 ± 0.5 |
29.7 ± 0.4 |
9.5 |
| Waist circumference (cm) |
86.3 ± 0.4 |
94.3 ± 1.0 |
95.1 ± 1.0 |
99.5 ± 0.9 |
13.4 |
| Serum fasting insulin (pmol/l) |
12.5 ± 0.3 |
15.9 ± 0.8 |
19.6 ± 1.4 |
23.3 ± 1.5 |
11.1 |
| Triglycerides (mmol/l) |
0.89 ± 0.02 |
1.17 ± 0.05 |
1.35 ± 0.10 |
1.55 ± 0.09 |
11.2 |
| LDL cholesterol (mmol/l) |
3.43 ± 0.04 |
3.73 ± 0.11 |
3.82 ± 0.10 |
3.98 ± 0.11 |
5.8 |
| HDL cholesterol (mmol/l) |
1.41 ± 0.02 |
1.30 ± 0.04 |
1.27 ± 0.04 |
1.21 ± 0.03 |
-6.5 |
| Systolic blood pressure (mmHg) |
123 ± 0.6 |
134 ± 1.6 |
136 ± 1.4 |
142 ± 1.5 |
13.1 |
| Mean intima-media thickness (n) |
258 |
76 |
93 |
126 |
|
| Carotid (mm) |
0.71 ± 0.01 |
0.72 ± 0.01 |
0.76 ± 0.02 |
0.80 ± 0.02 |
5.9 |
| Femoral (mm) |
0.81 ± 0.03 |
0.91 ± 0.07 |
1.04 ± 0.06 |
1.27 ± 0.07 |
8.3 |
| Total (mm) |
0.76 ± 0.02 |
0.82 ± 0.04 |
0.90 ± 0.03 |
1.04 ± 0.04 |
8.7 |
|
Values displayed are age-standardized means ± standard error. *z-value for trend; all corresponding p-values < 0.01. | |||||
Faeh et al. Cardiovascular Diabetology 2007 6:32 doi:10.1186/1475-2840-6-32 |
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