Original investigation
Serum leptin and its relation to anthropometric measures of obesity in pre-diabetic Saudis
1 Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia
2 Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia
3 Medicine Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia
4 Diabetic Center, KAUH, Riyadh, Saudi Arabia
5 Diabetic Center, KAUH, Riyadh, Saudi Arabia
6 Clinical Biochemistry, Birmingham Heartlands Hospital, Birmingham, B9 5SS, UK
7 Warwick Medical School, Diabetes & Metabolism Unit, University of Warwick, Coventry, CV4 7AL, UK
Cardiovascular Diabetology 2007, 6:18 doi:10.1186/1475-2840-6-18
Published: 7 July 2007Abstract
Background
Little information is available on leptin concentrations in individuals with IGT. This study aims to determine and correlate leptin levels to anthropometric measures of obesity in pre-diabetic, (IFG and IGT), type 2 diabetic and normoglycaemic Saudis.
Methods
308 adult Saudis (healthy controls n = 80; pre-diabetes n = 86; Type 2 diabetes n = 142) participated. Anthropometric parameters were measured and fasting blood samples taken. Serum insulin was analysed, using a solid phase enzyme amplified sensitivity immunoassay and also leptin concentrations, using radio-immunoassay. The remaining blood parameters were determined using standard laboratory procedures.
Results
Leptin levels of diabetic and pre-diabetic men were higher than in normoglycaemic men (12.4 [3.2–72] vs 3.9 [0.8–20.0] ng/mL, (median [interquartile range], p = 0.0001). In females, leptin levels were significantly higher in pre-diabetic subjects (14.09 [2.8–44.4] ng/mL) than in normoglycaemic subjects (10.2 [0.25–34.8] ng/mL) (p = 0.046). After adjustment for BMI and gender, hip circumference was associated with log leptin (p = 0.006 with R2 = 0.086) among all subjects.
Conclusion
Leptin is associated with measures of adiposity, hip circumference in particular, in the non-diabetic state among Saudi subjects. The higher leptin level among diabetics and pre-diabetics is not related to differences in anthropometric measures of obesity.
