Figure 5.

The proinflammatory effect of 1 μM heterodimeric S100A8/S100A9 on AGE pretreated HUVEC was reduced by blockers of the MAP-kinases Erk1/2 (PD98059) and p38 (SB 203580). Combined blocking of both MAP-kinases resulted in complete inhibition of NF-kappaB activation (a) and IL-6 release (b).