Figure 3.

Diabetes related alterations in loading-induced p38-MAPK phosphorylation in the IVC are isoform-specific. The basal (control) and pressure-induced phosphorylation of the p38-MAPK in venae cavae from non-diabetic lean Zucker (LNZ) and diabetic obese syndrome X Zucker (OSXZ) rats. Phosphorylation status of A.) p38γ-MAPK, B.) p38α-MAPK, and C.) p38β-MAPK was calculated as phosphospecific optical density divided by the unpressurized non-diabetic control value. * Significantly different from unloaded venae cavae within the same group (P < 0.05). † Significantly different from corresponding non-diabetic venae cavae (P < 0.05). n = 6/group.