Figure 2.

Diabetes alters loading-induced p44/42 phosphorylation in the IVC. The basal (control) and pressure-induced phosphorylation of the ERK1/2-MAPK in venae cavae from non-diabetic lean Zucker (LNZ) and diabetic obese syndrome X Zucker (OSXZ) rats. Phosphorylation status was calculated as phosphospecific optical density divided by the unpressurized non-diabetic control value. * Significantly different from unloaded venae cavae within the same group (P < 0.05). † Significantly different from corresponding LNZ venae cavae (P < 0.05). n = 6/group.