Figure 3.

Influence of metformin on IL-6 release and inhibiton of HMW-APM stimulated IL-6 by a NFκB inhibitor. (A) Monocytes from 3 controls were cultivated with 0.5 mM metformin for 24 h and IL-6 was determined. (B) Monocytes from 2 different donors were incubated with 10 μg/ml HMW-APM alone or in combination with 2.5, 5.0 or 10.0 μM InSolution™ NF-κB Activation Inhibitor for 24 h and IL-6 was measured.