|
Genes related to the insulin signaling cascade which are specifically modulated by OxLDL in comparison to mmLDL and vehicle in hyperinsulinemic hyperglycemic conditions. |
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| Mean absolute intensity |
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|
|
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| Description |
Locus Link |
Vehicle |
mmLDL |
OxLDL |
Fold change: OxLDL vs. Vehicle |
P: OxLDL vs. Vehicle |
P: OxLDL vs. mmLDL |
|
|
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| Insulin receptor |
3643 |
19.7 |
33.0 |
76.8 |
3.90 |
<0.004 |
<0.009 |
| Insulin receptor substrate 2 (IRS2) |
8660 |
193.0 |
199.0 |
471.1 |
2.44 |
<0.000001 |
<0.000001 |
| Glucose-6-phosphate dehydrogenase |
2539 |
1665.8 |
3410.6 |
3866.6 |
2.32 |
<0.000001 |
N.S.* |
| Insulin induced gene 1 (Insig-1) |
3637 |
1485.7 |
1024.8 |
274.6 |
-5.41 |
<0.000001 |
<0.000001 |
| Phosphoinositide-3-kinase. Catalytic; delta polypeptide (PIK3CD) |
5293 |
1890.4 |
1427.2 |
984.2 |
-1.92 |
<0.000001 |
= 0.001 |
|
*) N.S. – not statistically significant (p > 0.05). | |||||||
Shashkin et al. Cardiovascular Diabetology 2006 5:13 doi:10.1186/1475-2840-5-13 |
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