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A representation of proteoglycans I – IV present in vascular ECM |
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| Family (location) |
Common name |
Function |
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| I. Large (interstitial) |
Versican (CSPG) |
Compression resilience. Similar to Hyaluronan |
| II. Small (leucine-rich) |
Decorin Biglycan Lumican |
Collagen organization. |
| III. Basement membrane Recently discovered → In diabetic renal BM the CSPG Bamacan may be substituted for the HSPG Perlecan |
Perlecan (HSPG) Bamacan (CSPG) (galactosaminoglycan chains) Agrin (HSPG) |
Anionic filtration barrier Binds growth factors Neural tight junctions (Blood Brain Barrier) and in renal BM |
| IV. Cell surface (Plasma membrane). I.- IV. Present in vascular ECM The vascular SMC is the principal source for these vascular proteoglycans. |
Syndecan-1 Fibroglycan N-Syndecan (HSPG) Ryudocan Glypican (HSPG) |
ECM receptors, growth factor receptors. Binds coagulant enzymes, cytokines, and lipases. |
| V. Cerebral Proteoglycans Others: |
Cerebrocan Neurocan (CSPG) Phosphacan (CSPG) Brevican (CSPG) _______ Aggrecan Betaglycan |
Prominent in cartilage |
Hayden et al. Cardiovascular Diabetology 2005 4:9 doi:10.1186/1475-2840-4-9 |
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