|
Tissue wound injury: a common link between two chronic diseases: OSTEOATHEROITIS and OSTEOARTHRITIS. |
|
| T |
Tissue wound healing: a recapitulation of embryologic genetic memory |
| I |
Injury – Inflammation: OSTEOATHEROITIS – OSTEOARTHRITIS |
| G |
Granulation tissue formation (angiogenesis) |
| E |
Endothelial cell activation, proliferation, migration: ANGIOGENESIS |
| R |
Remodeling of the AVW: initially positive outward remodeling and over time a chronically negative inward arterial remodeling (see Scar contracture). Repair. Restructure. Resolution: results, only if the chronic injurious stimuli and sensitizers are removed from the endothelial, intimal, and medial layers of the arterial vessel wall. The above 4 (R's): activate pleuripotent mesenchymal stem-cell pericytes and VSMCs to produce bone morphogenic proteins, which are also activated by (I): Injury and Inflammation with resulting inflammatory cytokines such as TNF alpha, IL-6 and decreased IL-10. |
| S |
Scar: contracture and negative remodeling resulting in stenosis. AVW stiffness even without ossification. |
Hayden et al. Cardiovascular Diabetology 2005 4:4 doi:10.1186/1475-2840-4-4 |
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