|
Beneficial effects of HDL-C |
| REVERSE CHOLESTEROL TRANSPORT |
| Accepts cholesterol from the macrophage and tissues and transports it back to the liver for disposal in the bile (figure 1). |
| Acts a an apoprotein donor to the other lipoproteins |
| ANTIOXIDANT |
| Antioxidant activity (through intimal paraoxonase, and redox -sensitive methionine residues of apo A-1) |
| Increases eNOS and endothelial nitric oxide |
| ANTIINFLAMMATORY |
| Downregulates adhesion molecule expression on endothelium: (I-CAM, V-CAM and MCP-1) |
| Inhibits neutrophil degranulation |
| ANTITHROMBOTIC |
| Antithrombotic activity via its ability to block TxA2 and potentiates activity of proteins: C and S. |
| Stimulates prostacyclin production (antithrombotic and vasodilitory). |
| ENDOTHELIAL PROTECTION PROTERTIES |
| Acts as an endothelial mitogen and inhibits endothelial cell apoptosis: This would help to decrease the incidence of plaque erosion and promote plaque stabilization |
| Stimulates endothelial nitric oxide (eNO and its enzyme eNOS) and prostacyclin production with vasodilatation, antioxidant, and anti-inflammatory properties. |
Hayden and Tyagi Cardiovascular Diabetology 2005 4:1 doi:10.1186/1475-2840-4-1 |