Exercise increases serum endostatin levels in female and male patients with diabetes and controls
1 Department of Cardiology, Institute of Internal Medicine II, Medical University of Vienna, Währinger Gürtel 18-20, Vienna 1090, Austria
2 Department of Anaesthesiology, Intensive Care and Pain Management, Medical University of Vienna, Währinger Gürtel 18-20, Vienna 1090, Austria
3 Department of Medical-Chemical Laboratory Analysis, Medical University of Vienna, Währinger Gürtel 18-20, Vienna 1090, Austria
4 Department of Cardiology, Medical University of Vienna, Währinger Gürtel 18-20, Vienna 1090, Austria
Cardiovascular Diabetology 2014, 13:6 doi:10.1186/1475-2840-13-6Published: 6 January 2014
Type 2 diabetes mellitus (T2DM) is often associated with atherosclerotic changes in coronary vessels, most notably plaques. The angiostatic parameter endostatin is able to inhibit angiogenesis in tissue as well as in plaques and therefore plays an important role in physiological and pathological neovascularisation. The aim of the present study was to investigate sex-specific differences and the influence of exercise on circulating endostatin levels in patients suffering from diabetes, and control subjects.
In total, 42 T2DM-patients and 45 control subjects were investigated. They underwent a graded physical stress test (ergometry). Serum endostatin levels were measured in venous blood at rest and directly after reaching maximum workload.
Females showed significantly higher endostatin levels at baseline measurements compared to men, independently of their underlying disease. In both female and male T2DM-patients endostatin levels were significantly lower compared to controls. Both groups and sexes showed a significant increase of endostatin after physical stress, whereas the extent of endostatin-increase was between 10.59-15.05%.
Middle-aged healthy female individuals as well as female T2DM-patients showed higher circulating serum endostatin levels compared to males, suggesting a hormonal influence on baseline circulating endostatin amounts. Exercise-induced increase in endostatin is also observable in patients suffering from T2DM. Concerning vascularisation, lower endostatin levels in T2DM might be advantageous. Concerning plaque stability, lower levels might be prejudicial.
Clinical Trial Registration-URL: http://clinicaltrials.gov/ct2/results?term=NCT01165515 webcite