CNX-012-570 improves insulin signaling and reduces stress in DIO and db/db mice models: At the end of the treatment period in both DIO and db/db mice, both liver and skeletal muscle tissues were collected for the analysis of both insulin sensitivity and stress markers. (A & B) phospho-AKT levels in skeletal muscle (upper panel) and phospho-JNK levels in liver (lower panel) from both DIO and db/db mice study respectively. (C) phospho-mTOR (upper panel) and phospho-eIF2α (lower panel) levels from skeletal muscle from DIO mice. L- Lean control, D- DIO or db/db control, T- CNX-012-570 treatment. (D) Serum adiponectin levels from db/db mice study. Clear bar-lean control, black bar-db/db control, grey bar-CNX-012-570 treatment (2.5 mg/kg, orally once a day). Statistical comparison between control and treatment group was conducted by One-way ANOVA followed by Dunnett’s test (*P < 0.05, ** P < 0.01 and *** P < 0.001).
Anil et al. Cardiovascular Diabetology 2014 13:27 doi:10.1186/1475-2840-13-27