CNX-012-570 reduces body weight: (A & D) Body weight from both the treatment group was measured weekly. Open square-Lean control, closed square-HFD or db/db control and Triangle-CNX-012-570 treatment. (B & E) At end of the treatment period, different adipose depot weight was measured from both DIO and db/db mice study respectively. (C) Histology of inguinal adipose tissue sections were analyzed after H&E staining. Clear bar-lean control, black bar-HFD or db/db control, grey bar-CNX-012-570 treatment (3 and 2.5 mg/kg, orally once a day in DIO and db/db mouse respectively). All the values are expressed as Mean ± SEM. Statistical comparison between control and treatment group was conducted by One-way ANOVA followed by Dunnett’s test (*P < 0.05, ** P < 0.01 and *** P < 0.001).
Anil et al. Cardiovascular Diabetology 2014 13:27 doi:10.1186/1475-2840-13-27