CNX-012-570 improves insulin sensitivity and glucose tolerance in DIO and db/db mice. (A) OGTT in DIO mice on week 8 of treatment. Open square-Lean control, closed square -HFD control and Triangle-CNX-012-570 (3 mpk, qd). (D) Fed glucose levels in db/db mice study were monitored weekly. (B & E) Fasting insulin, (C & F) HOMA IR in both DIO and db/db mice were measured at week 8 and 6 respectively. Clear bar-lean control, black bar-HFD or db/db control, grey bar-CNX-012-570 treatment (3 and 2.5 mg/kg, orally once a day in DIO and db/db mouse respectively). All the values are expressed as Mean ± SEM. Statistical comparison between control and treatment group was conducted by One-way ANOVA followed by Dunnett’s test (*P < 0.05, ** P < 0.01 and *** P < 0.001).
Anil et al. Cardiovascular Diabetology 2014 13:27 doi:10.1186/1475-2840-13-27