Metabolic, hemodynamic and structural adjustments to low intensity exercise training in a metabolic syndrome model
1 Human Movement Laboratory, Sao Judas Tadeu University, Av. Taquari, 546, São Paulo/SP 03166-000, Brazil
2 Hypertension Unit, Heart Institute (InCor), Medical School of University of Sao Paulo, São Paulo/SP, Brazil
3 Translational Physiology Laboratory, Nove de Julho University, São Paulo/SP, Brazil
4 Federal University of Sergipe, Aracajú/SE, Brazil
5 Institute of Cardiology Dante Pazzaneze, São Paulo/SP, Brazil
Cardiovascular Diabetology 2013, 12:89 doi:10.1186/1475-2840-12-89Published: 18 June 2013
The increase in fructose consumption is paralleled by a higher incidence of metabolic syndrome, and consequently, cardiovascular disease mortality. We examined the effects of 8 weeks of low intensity exercise training (LET) on metabolic, hemodynamic, ventricular and vascular morphological changes induced by fructose drinking in male rats.
Male Wistar rats were divided into (n = 8 each) control (C), sedentary fructose (F) and ET fructose (FT) groups. Fructose-drinking rats received D-fructose (100 g/l). FT rats were assigned to a treadmill training protocol at low intensity (30% of maximal running speed) during 1 h/day, 5 days/week for 8 weeks. Measurements of triglyceride concentrations, white adipose tissue (WAT) and glycemia were carried out together with insulin tolerance test to evaluate metabolic profile. Arterial pressure (AP) signals were directly recorded. Baroreflex sensitivity (BS) was evaluated by the tachycardic and bradycardic responses. Right atria, left ventricle (LV) and ascending aorta were prepared to morphoquantitative analysis.
LET reduced WAT (−37.7%), triglyceride levels (−33%), systolic AP (−6%), heart weight/body weight (−20.5%), LV (−36%) and aortic (−76%) collagen fibers, aortic intima-media thickness and circumferential wall tension in FT when compared to F rats. Additionally, FT group presented improve of BS, numerical density of atrial natriuretic peptide granules (+42%) and LV capillaries (+25%), as well as the number of elastic lamellae in aorta compared with F group.
Our data suggest that LET, a widely recommended practice, seems to be particularly effective for preventing metabolic, hemodynamic and morphological disorders triggered by MS.