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Open Access Original investigation

Serum pigment epithelium-derived factor levels are independently correlated with the presence of coronary artery disease

Feifei Wang1, Xiaojing Ma1, Mi Zhou1, Xiaoping Pan1, Jie Ni1, Meifang Gao2, Zhigang Lu2, Jingyu Hang2, Yuqian Bao1* and Weiping Jia1

  • * Corresponding author: Yuqian Bao byq522@163.com

  • † Equal contributors

Author Affiliations

1 Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China

2 Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

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Cardiovascular Diabetology 2013, 12:56  doi:10.1186/1475-2840-12-56

Published: 1 April 2013

Abstract

Background

Pigment epithelium-derived factor (PEDF) has been proved to be closely correlated with metabolic syndrome (MetS) and its components that are all risk factors of cardiovascular disease and may play a protective role against vascular injury and atherosclerosis. The present study was designed to investigate the relationship between serum PEDF and coronary artery disease (CAD).

Methods

A total of 312 consecutive in-patients (including 228 with CAD and 197 with MetS) who underwent coronary angiography were enrolled. Serum PEDF was measured by sandwich enzyme immunoassay and used to carry out multivariate stepwise regression analysis to assess correlation with patient demographic and clinical parameters. Multiple logistic regression analysis was performed to identify factors independently correlated with CAD.

Results

Patients with MetS had significantly higher levels of serum PEDF than non-MetS subjects (11.1(8.2, 14.2) vs. 10.1(7.6, 12.4) μg/mL; P < 0.05). Patients with CAD also had significantly higher serum PEDF than non-CAD subjects (11.0(8.1, 14.2) vs. 10.3(8.1, 12.8) μg/mL; P < 0.05). Triglyceride (TG), C-reactive protein (CRP), estimated glomerular filtration rate (eGFR), and hypoglycemic therapy were independently correlated with serum PEDF levels, and serum PEDF was independently positively correlated with CAD.

Conclusions

Serum PEDF levels are independently positively associated with CAD in a Chinese population. Elevated PEDF may act as a protective response against vascular damage and subsequent CAD.

Keywords:
Atherosclerosis; Coronary angiography; Coronary artery disease; Metabolic syndrome; Pigment epithelium-derived factor