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Open Access Open Badges Original investigation

Influence of fibrinogen and C-RP on progression of peripheral arterial disease in type 2 diabetes: a preliminary report

Marijan Bosevski1, Golubinka Bosevska2 and Lily Stojanovska34*

Author Affiliations

1 Medical Faculty, University Cardiology Clinic, Skopje, Macedonia

2 Institute for Public Health of R. Macedonia, Skopje, Macedonia

3 College of Health and Biomedicine, Victoria University, Melbourne, Australia

4 School of Biomedical and Health Sciences, Victoria University, PO Box 14428, 8001, Melbourne, Vic, Australia

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Cardiovascular Diabetology 2013, 12:29  doi:10.1186/1475-2840-12-29

Published: 1 February 2013



Limited studies have suggested that inflammatory biomarkers play a role in the initiation and progression of atherosclerosis in diabetic patients. This study assesses the effect of inflammatory biomarkers: fibrinogen and C-reactive protein (C-RP) on the progression of peripheral arterial disease (PAD) in type 2 diabetic (T2D) patients.


Sixty two patients with T2D and PAD (mean age 60.28 ± 27 years and diabetes duration of 8.58 ± 6.17 years) were enrolled in a cohort prospective study of 36 months. Ankle-brachial index (ABI) was measured in all patients at baseline and after 36 months. Multiple linear regression analysis was used to determine the predictivity of variables for fibrinogen, C-RP, plasma lipid fractions, fasting plasma glucose, Body Mass Index (BMI), duration of diabetes status and the age on changes in ABI value.


Linear regression analysis defined F as a predictor for endpoint value of ABI (β = 0.469, p = 0.007). Value of C-RP determinates change of minimal value of ABI (β = 0.449, p = 0.037) and change of mean ABI per year (β = 0.442, p = 0.025).


Our data indicate that plasma determination of fibrinogen and C-RP might have a clinical implication in defining the process of progression of PAD in T2D population.

ABI; Fibrinogen; C-RP; Type 2 diabetes; Peripheral arterial disease; Progression of atherosclerosis