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Open Access Open Badges Original investigation

Serum osteocalcin level and its association with carotid atherosclerosis in patients with type 2 diabetes

Li Sheng1, Wenjie Cao2, Bingbing Cha1, Zhaoping Chen1, Fang Wang1 and Jun Liu1*

Author Affiliations

1 Department of Endocrinology, Shanghai Fifth People’s Hospital, Fudan University, 801 Heqing Road, Shanghai, China

2 Department of Neurology, Huashan hospital, Shanghai medical college, Fudan University, 12 Middle Wulumuqi Road, Shanghai, China

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Cardiovascular Diabetology 2013, 12:22  doi:10.1186/1475-2840-12-22

Published: 23 January 2013



To investigate the association of serum osteocalcin with carotid atherosclerosis in patients with type 2 diabetes.


We performed a cross-sectional community-based study in metropolitan area. Serum total osteocalcin was measured by radioimmunoassay in 382 men and 435 postmenopausal women. The carotid artery intima-media thickness (IMT) and carotid plaques (PLQ) were measured by B-mode ultrasound.


The crude mean of serum osteocalcin concentrations were 4.52±2.43 ng/ml for men and 5.75±2.92 ng/ml for postmenopausal women (P <0.001), respectively. Osteocalcin levels were associated inversely with age, fasting serum insulin, HOMA-IR, ALT, triglycerides, total cholesterol, LDL- cholesterol, CRP (all P<0.001) and positively with adiponectin and HOMA-B (all P<0.05). After multiple adjustment, the odds ratios (ORs) were substantially higher risk for carotid plaques (OR 1.77 for 1 SD decrease in osteocalcin, 95% CI 1.23-2.76, p=0.005). These associations remained significant after further adjustment for potential confounder.


Serum osteocalcin levels is an independent risk factor for carotid atherosclerosis in patients with type 2 diabetes.

Osteocalcin; Intima-media thickness; Carotid atherosclerotic plaques; Atherosclerosis