Original investigation
Glycosylated hemoglobin (HbA1c) levels and clinical outcomes in diabetic patients following coronary artery stenting
1 Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
2 Research Department, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
3 Department of Clinical and Surgical Pathology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
4 Students’ Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran
5 Endocrinology and Metabolism Research Center (EMRC), Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
6 Sina Trauma Research Center,Tehran University of Medical Sciences, Tehran, Iran
7 Tehran Heart Center, 1411713138, Karegar Shomali St., Jalal al-Ahmad Cross, Tehran, Iran
Cardiovascular Diabetology 2012, 11:82 doi:10.1186/1475-2840-11-82
Published: 17 July 2012Abstract
Background
Diabetes has been shown to be independent predictor of restenosis after percutaneous coronary intervention (PCI). The aim of the present study was to investigate whether a pre- and post-procedural glycaemic control in diabetic patients was related to major advance cardiovascular events (MACE) during follow up.
Methods
We evaluated 2884 consecutive patients including 2181 non-diabetic patients and 703 diabetics who underwent coronary stenting. Diabetes mellitus was defined as the fasting blood sugar concentration ≥ 126 mg/dL, or the use of an oral hypoglycemic agent or insulin at the time of admission. Diabetic patients were categorized into two groups based on their mean HbA1c levels for three measurements (at 0, 1, and 6 months following procedure): 291 (41.4%) diabetics with good glycaemic control (HbA1c ≤ 7%) and 412 (58.6%) diabetics with poor glycaemic control (HbA1c > 7%).
Results
The adjusted risk of MACE in diabetic patients with poor glycaemic control (HbA1c > 7%) was 2.1 times of the risk in non-diabetics (adjusted HR = 2.1, 95% CI: 1.10 to 3.95, p = 0.02). However, the risk of MACE in diabetics with good glycaemic control (HbA1c ≤ 7%) was not significantly different from that of non-diabetics (adjusted HR = 1.33, 95% CI: 0.38 to 4.68, p = 0.66).
Conclusions
Our data suggest that there is an association between good glycaemic control to obtain HbA1c levels ≤7% (both pre-procedural glycaemic control and post-procedural) with a better clinical outcome after PCI.
