Table 3

Pharmacokinetic properties of ARBs [49,50,79]

tmax(h)

Bioavailability (%)

T1/2

(h)

Vd

(L)

Interaction with food

Hepatic elimination (%)


Candesartan

3.0-5.0

42

9-13

0.13 (L/kg)

No

67


Eprosartan

2.0-6.0

13

5-7

308

No

90


Irbesartan

1.0-2.0

60-80

12-20

53-93

No

80


Losartan

1.0 (3.0-4.0)1

33

2 (4-6)1

34 (12)1

No

60


Olmesartan

1.4-2.8

262

11.8-14.7

15-20

No

51-663


Telmisartan

1

43

24

500

No

> 984


Valsartan

2

23

7

17

No

83


Azilsartan

1.5-3.0

60

11

16

No

55


Abbreviations: ARB = angiotensin II receptor blocker; t1/2 = terminal elimination half-life; tmax = time to maximum plasma concentration; Vd = volume of distribution

1 Values in parentheses are for the active metabolite of losartan

2 For olmesartan medoxomil

3 Based on urinary recovery rate for intravenous olmesartan

4 Faecal recovery for telmisartan

Mallat Cardiovascular Diabetology 2012 11:32   doi:10.1186/1475-2840-11-32

Open Data