Table 4 |
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|
Echocardiography parameters in STZ-treated hyperglycemic, STZ-treated euglycemic, and vehicle treated control rats at 2, 4, 6, and 8 weeks after STZ |
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|
Control |
STZ, Euglycemic |
STZ, Hyperglycemic |
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|
2 Weeks |
4 Weeks |
6 Weeks |
8 Weeks |
2 Weeks |
4 Weeks |
6 Weeks |
8 Weeks |
2 Weeks |
4 Weeks |
6 Weeks |
8 Weeks |
|
|
|
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|
EV (d) (μL) |
477 ± 135 |
477 ± 65 |
431 ± 90 |
353 ± 43 |
570 ± 47 |
457 ± 100 |
400 ± 67 |
363 ± 35 |
435 ± 103 |
497 ± 117 |
483 ± 80 |
369 ± 111 |
|
EV (s) (μL) |
199 ± 49 |
184 ± 72 |
137 ± 35 |
128 ± 19 |
192 ± 33 |
134 ± 39 |
160 ± 9 |
95 ± 23 |
189 ± 57 |
182 ± 42 |
162 ± 36 |
119 ± 37 |
|
SV (μL) |
278 ± 122 |
293 ± 30 |
293 ± 58 |
225 ± 27 |
379 ± 81 |
323 ± 118 |
240 ± 76 |
268 ± 21 |
262 ± 57 |
314 ± 86 |
321 ± 52 |
250 ± 79 |
|
CO (mL/min) |
105 ± 52 |
106 ± 15 |
112 ± 16 |
81 ± 11 |
138 ± 47 |
113 ± 37 |
93 ± 18 |
100 ± 13 |
82 ± 23 |
91 ± 18 |
94 ± 19 |
69 ± 22 |
|
IVCT (ms) |
62 ± 5 |
79 ± 13 |
70 ± 6 |
64 ± 9 |
84 ± 5 |
74 ± 7 |
65 ± 7 |
73 ± 6 |
83 ± 14 |
81 ± 14 |
83 ± 15 |
78 ± 6 |
|
IVRT (ms) |
22 ± 4 |
33 ± 5 |
25 ± 8 |
32 ± 7 |
23 ± 0 |
30 ± 5 |
31 ± 2 |
24 ± 6 |
27 ± 6 |
25 ± 4 |
34 ± 15 |
33 ± 5 |
|
A (cm/s) |
62 ± 22 |
77 ± 13 |
85 ± 33 |
77 ± 25 |
59 ± 6 |
83 ± 22 |
65 ± 17 |
97 ± 23 |
50 ± 13 |
65 ± 21*† |
58 ± 39 |
69 ± 19*† |
|
E (cm/s) |
98 ± 5 |
118 ± 23 |
92 ± 26 |
98 ± 19 |
105 ± 5 |
119 ± 22 |
92 ± 8 |
125 ± 42 |
92 ± 18 |
104 ± 24 |
98 ± 28 |
99 ± 21 |
|
E/A Ratio |
1.7 ± 0.5 |
1.6 ± 0.3 |
1.2 ± 0.4 |
1.3 ± 0.3 |
1.8 ± 0.1 |
1.5 ± 0.2 |
1.4 ± 0.3 |
1.3 ± 0.2 |
1.9 ± 0.6 |
1.7 ± 0.3 |
2.0 ± 1.0 |
1.5 ± 0.3 |
|
|
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|
* p < 0.05 to controls, † p < 0.05 to euglycemic, one-way ANOVA, Bonferroni post hoc (EV = endocardial volume at diastole (d) or systole (s); SV = stroke volume; CO = cardiac output; IVCT = intraventricular contraction time; IVRT = isovolumic relaxation time; A = transmitral atrial (late) filling velocity; E = transmitral early filling velocity) Calculations: EV (d) = (4π/3) × (Endo Major (d)/2) × ((Endo Area (d))/π (Endo Major (d)/2))2 EV (s) = (4π/3) × (Endo Major (s)/2) × ((Endo Area (s))/π (Endo Major (s)/2))2 SV = EV(d) - EV (s) EF = SV/EV (d) × 100% FAC = (Endo Area (d) - Endo Area (s))/Endo Area (d) × 100% CO = SV × Heart Rate |
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|
Thackeray et al. Cardiovascular Diabetology 2011 10:75 doi:10.1186/1475-2840-10-75 |
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