Interleukin-6 (A) and TNF-α (B) immunostaining of islets of Langerhans (original magnification 400×) in ZDF rats. (A1 and B1) - Staining of the islet of a 20-wk-old sedentary diabetic (fa/fa) rat showing high immunostaining (+++); (A2 and B2) - Staining of the islet of a 20-wk-old exercised diabetic (fa/fa) rat with a significant reduction in the expression of interleukin-6 (A) and TNF-α (B) immunoreactivity (+).IL-6, interleukin 6; TNF-α, tumour necrosis factor α. Adapted from ).
Teixeira-Lemos et al. Cardiovascular Diabetology 2011 10:12 doi:10.1186/1475-2840-10-12