Table 1

Atherosclerosis promoting effects of AGEs: Non-Receptor Mediated Mechanisms

Extracellular matrix

Collagen cross linking [74]

Enhanced synthesis of extracellular matrix components [10]

Trapping of LDL in the subendothelium [75]

Glycosylated subendothelial matrix quenches nitric oxide [76]

Functional alterations of regulatory proteins

bFGF glycosylation reduces its heparin binding capacity and its mitogenic activity on endothelial cells [13]

Inactivation of the complement regulatory protein CD59 [26]

Lipoprotein modifications

Glycosylated LDL [19,20]

Reduced LDL recognition by cellular LDL receptors [21]

Increased susceptibility of LDL to oxidative modification [19]


Aronson and Rayfield Cardiovascular Diabetology 2002 1:1   doi:10.1186/1475-2840-1-1

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