Table 1 |
|
Atherosclerosis promoting effects of AGEs: Non-Receptor Mediated Mechanisms |
|
Extracellular matrix |
|
Collagen cross linking [74] |
|
Enhanced synthesis of extracellular matrix components [10] |
|
Trapping of LDL in the subendothelium [75] |
|
Glycosylated subendothelial matrix quenches nitric oxide [76] |
|
Functional alterations of regulatory proteins |
|
bFGF glycosylation reduces its heparin binding capacity and its mitogenic activity on endothelial cells [13] |
|
Inactivation of the complement regulatory protein CD59 [26] |
|
Lipoprotein modifications |
|
Reduced LDL recognition by cellular LDL receptors [21] |
|
Increased susceptibility of LDL to oxidative modification [19] |
|
|
|
Aronson and Rayfield Cardiovascular Diabetology 2002 1:1 doi:10.1186/1475-2840-1-1 |
