|
Atherosclerosis promoting effects of AGEs: Non-Receptor Mediated Mechanisms |
| Extracellular matrix |
| Collagen cross linking [74] |
| Enhanced synthesis of extracellular matrix components [10] |
| Trapping of LDL in the subendothelium [75] |
| Glycosylated subendothelial matrix quenches nitric oxide [76] |
| Functional alterations of regulatory proteins |
| bFGF glycosylation reduces its heparin binding capacity and its mitogenic activity on endothelial cells [13] |
| Inactivation of the complement regulatory protein CD59 [26] |
| Lipoprotein modifications |
| Glycosylated LDL [19,20] |
| Reduced LDL recognition by cellular LDL receptors [21] |
| Increased susceptibility of LDL to oxidative modification [19] |
Aronson and Rayfield Cardiovascular Diabetology 2002 1:1 doi:10.1186/1475-2840-1-1 |